The department of Structural Biology within Genentech Research and Early Development (gRED) seeks a Computational Scientist to join its cryo-EM team. You will support drug discovery and research across therapeutic areas by designing, implementing and integrating new software tools, as well as by processing data using established pipelines.
The department offers a highly interdisciplinary environment with unparalleled resources and unique opportunities for scientific collaboration and growth. They integrate crystallography, cryo-EM, and NMR to drive drug discovery and fundamental biology research. Their cryo-EM facility is equipped with state-of-the-art microscopes and leverages extensive HPC resources for data processing. We also actively support and lead the development of widely used, cutting-edge cryo-EM software, ranging from AI-enabled image processing tools to information and workflow management systems.
Responsibilities
Responsibilities will be tailored to your interests and skills, and to Department needs, but will likely include a combination of some of the following:
Develop and integrate the next generation of cryo-EM data collection and processing solutions
Contribute to in-house and public open-source software development
Collaborate with the Scientific Computing group to maintain and evolve the computational infrastructure for cryo-EM, and better integrate it with gRED’s broader informatics systems
Benchmark and document data processing pipelines and optimize hardware utilization
Provide training, advice and support to researchers and collaborators new to cryo-EM data processing
Work with Structural Biology scientists and researchers to optimize image processing strategies for a range of challenging targets
Process cryo-EM image datasets to obtain high-resolution structures and support research and drug discovery efforts
Co-author publications describing structural biology results, methods, and new software
Present results at internal, regional and international meetings and conferences
Qualifications
Advanced degree (MS or PhD) with 2 or more years of relevant professional experience; or BA/BS with at least 5 years of relevant professional experience
Desirable experience
Demonstrated ability to solve high-resolution structures of challenging samples using modern cryo-EM tools
Knowledge of one or more programming languages (Python, C#, C++, Rust, or similar) and tool sets (IDEs, compilers, libraries, version control systems)
