The Francis Crick Institute seeks to recruit a cryo-electron microscopy (Cryo-EM) specialist to lead its state-of-the-art facility.
The post-holder for this role will further develop and deliver a state-of-the-art Cryo-EM facility featuring a wide range of Cryo-EM modalities to support Crick science.
The Crick has excellent Cryo-EM facilities, with two Titan Krios 300kV instruments, one fitted with a Gatan energy filter and K2 detector plus Falcon 4i and the other with a Selectris energy filter and Falcon 4i. These microscopes are complemented by a Talos Arctica 200kV and a Glacios 200kV, both with Falcon 3 detectors, and used for cryo-screening and preliminary data collection, together with two 120kV Spirit TEM microscopes, primarily used for negative-stain. The SB STP is currently installing and commissioning an Aquilos-2 Cryo-FIB instrument and will be incorporating it into our Cryo-ET pipeline. The Crick also has excellent High Performance Computing resources, with access to dedicated high-speed data storage and CPU and GPU clusters.
There are currently more than 25 Crick groups whose research depends on Cryo-EM encompassing about 67 scientists at the PhD, postdoc and research scientist levels.
The Cryo-EM Specialist role will with the Cryo-EM microscope manager and lead the team to manage and develop the Cryo-EM facility. This will include overseeing the establishment of new collaborative projects, the development of new techniques, the design and implementation of training programmes in Cryo-EM and ensure the effective and safe running of this service. The role will participate in multidisciplinary teams across different STPs and science groups, supervising (either formally or informally) staff or students as needed, including oversight and direction on techniques, as well as consultation on project work. They will serve as a subject matter expert for other research staff.
