A Post-Doc position is available in molecular modelling (biocomputing) within the framework of an ANR-funded project between the Institute of Genetics and Molecular and Cellular Biology (IGBMC) in Strasbourg France and the Toulouse Biotechnology Institute (TBI) in Toulouse France.
Job description
The successful candidate will be a key member of the ANR-funded research project PyoClick aims that to investigate and design non-ribosomal peptide synthases (NRPS) in the bioproduction of new-to-nature peptides for biomedical applications.
The candidate will be in charge of conducting molecular modelling studies to get a better understanding of molecular determinants in the involvement in the function and substrate recognition of the targeted enzyme. The project will also aim at redesigning the enzyme to achieve the intended catalytic reaction and drive experimental construction of enzyme mutant libraries. This work carried be out in close interaction with our experimental collaborators in charge of enzyme engineering and evaluation tasks.
They are looking for a motivated scientist who has a sound understanding of protein modelling and protein-ligand interactions. He/She should have research expertise/training in a number of areas of computational biology, including protein modelling, molecular docking, molecular dynamics simulations and computational protein design. Experience in sequence analysis and familiarity with emerging design tools based on AI would be a plus. Knowledge of the Linux system operating is expected. She/He will will apply a range of molecular modeling and bioinformatics techniques (sequence analysis, protein structure prediction, molecular docking, molecular dynamics simulations, free prediction energy ...) to decipher essential structural and dynamical determinants of NRPS enzyme function and engineering.
The perspective post-doc will have the opportunity to work in a diverse and rich multidisciplinary environment, surrounded by both computational and experimental experts in the fields of enzyme catalysis, design and engineering. The successful candidate should enjoy teamwork and have very good communication skills. Good English skills are required and notions of French be would a plus. He/She will be a key player in this collaboration between the IGBMC and TBI laboratories.
Qualifications
• PhD in Molecular Modelling, Structural bioinformatics, Biophysics or related field.
• Essential skills required include protein modelling, biomolecular simulation, and bioinformatics methods and techniques.
• Strong communication and organizational skills willing and to work in a team-oriented environment.
• Good English skills are required and notions of French would be a plus.
The position is available starting from January 1st, 2026 and for a duration of 12 months (with possible renewal).
Applicants should send a detailed curriculum vitae, a letter of explanation intent their motivations for the position, and contact details of at least two references. Send your applications to:
Roland Stote: rstote@igbmc.fr
Jérémy Esque: esque@insa-toulouse.fr
Application deadline 30th November 2025
