The Cogan Laboratory at the University of Southern California (USC) in the Department of Pharmacology and Pharmaceutical Sciences is seeking a highly motivated postdoctoral researcher to investigate the mechanisms of polyketide biosynthesis. The selected individual will use biochemical and biophysical techniques, including single-particle cryogenic electron microscopy (cryo-EM), to address key unsolved problems related to polyketide synthase architecture and catalysis.
USC is equipped with the necessary hardware and software infrastructure to perform cutting edge cryo-EM research. The Core Center of Excellence in Nano Imaging (CNI) at USC houses two cryogenic transmission electron microscopes: a Thermo Scientific Titan Krios G3i and a Thermo Scientific Glacios, both equipped with direct electron detectors, along with a Thermo Scientific Vitrobot plunge-freezing apparatus and other necessary tools for cryo-EM grid preparation. Computing resources for cryo-EM data analysis are available through USC's Center for Advanced Research Computing.
Qualifications: Candidates must hold a Ph.D. in Chemistry, Biochemistry, Biophysics, Structural Biology, Chemical Biology, Medicinal Chemistry, Molecular Biology, or a related field. All qualified candidates will be considered, although preference will be given to those with prior experience in protein purification, analytical biochemistry, structural biology, molecular biology, chemical biology, and/or microbiology.
Interested candidates should send their CV and a list of three references to Dillon Cogan at dcogan@usc.edu.