Jobs in Structural Biology and Related Fields

Applications are invited for a postdoctoral scientist to investigate the mechanisms of RNA binding mediated by disordered regions lacking conventional RNA binding annotations in the laboratory of Professor Maria R (Sasi) Conte, Randall Centre for Cell and Molecular Biophysics, King’s College London. 

ABOUT US 

Our lab specialises in understanding the detailed mechanisms of interaction between proteins and RNA, with a major focus on the La-related proteins (LARPs). We use a combination of structural biology, biophysics and biochemistry techniques and work closely with interdisciplinary collaborators to test hypotheses in the context of cell biology and model organisms.   

WE ARE LOOKING FOR  

a skilled, motivated and enthusiastic postdoctoral candidate with a strong interest in protein-RNA interactions and biophysics. The project will focus on the LARPs involved as key regulators of gene expression via a variety of mechanisms.  

The successful applicant will find themselves working in a dynamic, interdisciplinary and exciting research environment and will be based in the Randall Centre on the Guy’s Campus, London, UK. The project will be supported by the state-of-the-art infrastructure of the Centre for Biomolecular Spectroscopy and the Randall Centre. 

REQUIREMENTS  

The successful candidate will have most of the following characteristics:   

• A Ph.D. degree in biophysics, biochemistry, structural biology or related field  
• Experience in NMR spectroscopy of proteins and/or RNA 
• Demonstrated proficiency in a range of biophysical and structural biology techniques (e.g. CD, fluorescence spectroscopy, EMSA, titration calorimetry, mass spectrometry, SAXS, X-ray crystallography)  
• The ability to perform, interpret and integrate the results of biophysical and biochemical experiments  
• Proficiency in molecular biology and protein expression and purification 
• The ability to adapt, develop and implement methods as dictated by the progress of the investigations 
• Prior expertise in SAXS/SANS would be highly advantageous 
• Experience in intrinsically disordered proteins would be a plus 
• The capability to plan and execute experimental work without close supervision  
• The ability to work as part of a team