Jobs in Structural Biology and Related Fields

Group/ Team Leader – Integrated X-ray based structural biology and dynamics at EMBL

EMBL Hamburg, Hamburg , Germany

Application deadline: 08 Aug 2021

We are seeking to recruit a group leader with expertise in small-angle X-ray scattering methods to develop and oversee X-ray based structural biology research and services at the present PETRA III and the future PETRA IV synchrotron. Areas of high interest are new approaches for time-resolved structural studies, for structural studies of intrinsically unfolded proteins, and for bridging molecular structural biology into cellular/organismal imaging.

EMBL’s future scientific directions, From Molecules to Ecosystems, include a vision to advance our understanding of ecosystems at the molecular level, applying expertise in molecular biology to study life in its natural context. New research areas will focus on applying experimental, computational and theoretical approaches to study at multiple levels (molecules, cells, tissues and populations) how organisms interact with each other and respond to environmental change. New approaches will be developed both for future EMBL research activities and external services.

Within this concept, the EMBL Hamburg Unit will continue to develop its research services for X-ray crystallography (MX) and small-angle X-ray scattering (SAXS), including facilities for sample preparation and characterization. Our services are complemented by a research program comprising membrane protein complexes, integrative structural modeling approaches, and X-ray imaging of cellular structures and organisms. Here we are looking for a candidate with main expertise in the field of biological SAXS technical developments and applications as well as a strong interest for combining this expertise with other methods. Areas of interest are time-resolved studies of structural dynamics, development of new concepts for understanding disordered parts of protein complexes, as well as integrative approaches bridging molecular structural biology and cellular imaging.

Your role

• Establish an independent and innovative research program towards new SAXS approaches on biological samples, encompassing experimental, technical and/or computational developments.
• Contribute to the operation and development of the EMBL research infrastructures at PETRA III, as well as preparing, implementing and operating future EMBL research infrastructures in structural biology at the planned PETRA IV synchrotron storage ring.
• Integrate and combine future SAXS applications with other methodologies in structural biology, as implemented across different EMBL sites.
• Engage into an advanced external and internal training program, with emphasis on high-end methodology and instrumentation.

You have

• A PhD in a relevant research area, and a proven post-doctoral research record in a relevant field.
• Profound expertise in Small angle X-ray scattering and/or related biophysical and structural biology methods.
• Proven track record of developing new technologies.
• Strong motivation to work in a highly collaborative and multidisciplinary environment.
• A concise research plan with clearly outlined, original and ambitious research goals. 
• In addition, you should be dedicated to develop effective relationships and to provide leadership and guidance to team members.
• The ability to work independently and to participate in a collaborative team effort is desirable, as is a pro-active and positive problem solving mind-set.
• Fluency in English is essential. 

Apply now

Closing date: 8 August 2021

Contract duration: 5 years

Grading: 9

Reference number: HH00201

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