Providing access to structural biology facilities

 

iNEXT-Discovery offers facility access and expert support to all European scientists for their translational research in the wider field of structural biology, regardless of prior expertise or familiarity with the methods. If you are a cell biologist, a biochemist, a medicinal chemist, working with biomaterials or biotechnology, or work in the food sector, and you have a research question that involves knowledge of the structures of biomolecules and their interactions you can apply for access with iNEXT-Discovery. We specifically encourage researchers with no prior expertise in structural biology to apply for access.

 

The iNEXT-Discovery structural biology facilities are specialized in the following areas:

  • X-ray crystallography and SAXS
  • Nuclear Magnetic Resonance, liquid and solid state, and in-cell (see here our recent inventory on time-resolved NMR)
  • cryo-Electron Microscopy, single-particle and tomography
  • Macromolecular biophysics

 

Applications addressing SARS-CoV-2 and/or Covid-19 and mentioning this in the title will be funneled towards rapid review. Operational facilities will prioritize such projects if they can be accommodated. Do not worry if the facility is closed or open or if it has the required safety protocols: just send us your idea!

To apply for access you will need to have the material that you want to study (e.g. a purified protein, or a macromolecular complex, small molecules, DNA, RNA, etc). If you want to study specific proteins or complexes and you do not have the purified macromolecules, please consider contacting our partner Instruct-ERIC!

iNEXT-Discovery will peer-review your proposal for scientific excellence in the context of the goals of the project to enable translation research. Access provided by iNEXT-Discovery does not involve access fees; also travel, accommodation and shipment of samples can be supported to some extent.

Access to our facilities should be cross-border (trans-national). All researchers from academia and industry, from Europe and beyond, can ask for access.

We have an on-line submission system that allows continuous submission of user proposals. Periodically there will also be specific calls for the health, food, biotechnology, and biomaterials communities. Submitted proposals are peer-reviewed by external referees on scientific quality, and also for technical feasibility by the facility experts.

All access requests should have a clear 'translational component' and bridging structural biology research with applications in biomedical, biotechnological, biomaterial, food or environmental research.

 

Our access criteria are summarized as follows:

  DO I QUALIFY FOR ...

 

ACADEMIA

INDUSTRY

(SME)

INDUSTRY

(non-SME)

   ... peer-reviewed access?  
AND ...   must I acknowledge iNEXT-Discovery?
AND ...   must I attempt to publish my data?
AND ...   should I publish as Open Access?
   ... "pay-for-service" access?  
   ... workshops and training?  

What do I need to start my application?

We will ask you to choose first the "route" that best fits your project, then choose one or more facilities that could be performing it, and then to describe the research background, research objectives, and the translational value of your project. More detailed information will be available as case-specific help text for all applications!

Our general Access Guidelines can be found here.

For applying for access, please follow this link or click the big red button on the top-right ("Apply for Access")!

 

Some access specifics

  • Users can have access to EMBL sites even if they reside in the same country as the facility.
  • Remote access can be tolerated if the users are residing in the same country provided that a similar facility also exists in another country.
  • We can accept proposals from non-EU countries up to a limited capacity.
  • To enable peer-reviewed industry access (free) some reviewers have signed Confidentiality Agreements with iNEXT-Discovery.
  • Costs for travel and accommodation can be reimbursed from the facility (always following local regulations).
  • All publications should acknowledge iNEXT-Discovery:

“This work benefited from access to [the Name of facility] and has been supported by iNEXT-Discovery, project number 871037, funded by the Horizon 2020 program of the European Commission”

 

The following facilities provide access in iNEXT-Discovery:

FACILITY LOCATION TECHNOLOGY CONTACT EMAIL*
ABSL UK, Leeds EM Rebecca Thompson cryoEM@leeds.ac.uk
ALBA ES, Barcelona Xray Maria Jose Simancas useroffice@cells.es
AU DK, Aarhus EM Thomas Boesen thb@mbg.au.dk
CBI FR, Strasbourg EM Marie-Christine Poterszman pmarie@igbmc.fr
CEITEC CZ, Brno NMR, EM Katerina Vagnerova core.facility@ceitec.muni.cz
CIRMMP/CERM IT, Florence NMR   cirmmp@cerm.unifi.it
CSIC ES, Madrid EM Javier Chichon fjchichon@cnb.csic.es
DIAMOND UK, Didcot Xray, EM Nicola Harrington nicola.harrington@diamond.ac.uk
EMBL-GR FR, Grenoble Xray    
EMBL-HD DE, Heidelberg EM Felix Weis cryo-em@embl.de
EMBL-HH DE, Hamburg Xray (MX, SAXS)    
GUF/BMRZ DE, Frankfurt NMR Christian Richter ric@nmr.uni-frankfurt.de
HZB DE, Berlin Xray    
MAX IV SE, Lund Xray    
NeCEN NL, Leiden EM Ludovic Renault l.renault@biology.leidenuniv.nl
NKI NL, Amsterdam Interactions Hans Wienk h.wienk@nki.nl
RALF-NMR FR, Lyon/Grenoble NMR (LY, GR)    
SOLEIL FR, Paris Xray    
UU NL, Utrecht NMR Andrei Gurinov a.gurinov@uu.nl

* When contacting the facility, please mention "iNEXT-Discovery" in the subject!