iNEXT-Discovery was a structural biology project funded from the European Commission Horizon 2020 scheme until August 2024. The partnership involved twenty-six top-notch European structural biology groups that efficiently built on the first iNEXT consortium. iNEXT-Discovery made X-ray-based, NMR, cryo-EM and macromolecular biophysics access services available to external users, often researchers without prior experience in the methodology. Through joint research, the partners developed tools, pipelines and applications, thus stimulating integration of structural biology methods and data. During many meetings, theoretical courses, and practical workshops the consortium reached out to researchers from related fields.