News Articles

Instruct-ERIC is hiring a Director to join the Instruct Hub

Apply by 15 October 2020 to join the Instruct Hub as Director of Instruct-ERIC. The initial 5-year appointment is renewable based on performance.   The Integrated Structural Biology - European Research Infrastructure Consortium (Instruct-ERIC) is a pan-European distributed infrastructure whose principal task is to support excellent science that integrates an understanding of biological structure with cellular function. With 15 Members and one Observer, Instruct-ERIC provides open access ...

Royal Society Gabor Medal awarded to Instruct-ERIC Director Prof David Stuart

Congratulations to Instruct-ERIC director, Professor David Stuart, who has been awarded the prestigious Gabor Medal by the Royal Society. The Gabor Medal 2020 has been awarded to Professor Stuart for his seminal contributions to understanding virus structure and application to vaccine design, as well as driving the application of engineering and physical science to the life sciences. The Gabor Medal is awarded annually for acknowledged distinction of interdisciplinary work between the life scie...

Closing soon: apply for free vaccine development services through TRANSVAC2 Open Call

Apply by 5 August 2020. The European vaccine infrastructure, TRANSVAC2, is accepting applications for its Open Call, offering free technical services for all stages of vaccine development. TRANSVAC2, which is coordinated by the European Vaccine Initiative, offers high-quality technical services for the development of prophylactic and therapeutic vaccines for human and animal use. The Open Call covers all stages of the vaccine research and development pipeline, including Instruct-ERIC’s e...

European Research Infrastructures set to play a key role in addressing Horizon Europe Missions

As Europe prepares for the Commission’s most ambitious research and innovation funding programme to date, two recent position papers explain how European Research Infrastructures will help to deliver key scientific breakthroughs in the years ahead.     European Research Infrastructures (EU RIs) are organisations that facilitate excellent science by providing access to cutting-edge technology and resources. Over many years, EU RIs have helped to deliver important research progra...

Welcoming Lithuania as an Instruct-ERIC Member Country

The Instruct-ERIC consortium continues to grow, as Lithuania is welcomed as our newest Member Country. Researchers in Lithuania are now eligible to apply for funding to use structural biology services at all Instruct Centres, as well as training courses, internships, and R&D awards. Lithuania is an innovative country with long-standing traditions in molecular and structural biology. “Fermentas”, a well-known producer of restriction enzymes (acquired by Thermo Fisher Scientific i...

The quality control training school: a joint Instruct-ULTRA and ARBRE-MOBIEU course

  In October 2019, eleven early-career scientists from institutes across Europe gathered at the Institut Pasteur in Paris, to gain hands-on training in quality control for structural studies. Quality control is a critical practice for ensuring the integrity, reliability, and reproducibility of structural biology data. In particular, quality control provides important, reportable checkpoints that can be used to independently assess the conclusions drawn from structural biology data. The w...

Robotein high-throughput facility joins Instruct Centre BE

From 8 July 2020, Robotein® will be offering its expert facilities in high-throughput protein production and analysis through the Instruct-ERIC catalogue. The Robotein platform, which is hosted at the Centre for Protein Engineering (CIP) at the Université de Liège (ULiège), and the Structural Biology and Bioinformatics Centre (SBBC) at the Université Libre de Bruxelles (ULB), offers automated screening for optimal recombinant protein expression, purification and f...

Instruct Centre IT open for remote access, including powerful 1.2 GHz NMR spectrometer

Instruct Centre IT invites Instruct users to apply for remote access to the CERM/CIRMMP research infrastructure, which now includes the 1.2 GHz NMR spectrometer – the most powerful commercial NMR in the world. For ease of access during the COVID-19 pandemic, Instruct Centre IT has reinforced its well-established remote operations. Once an application to Instruct-ERIC has been approved, users can contact CERM/CIRMMP to plan the experiments and arrange sample shipment. When accessing Instru...

The virtual Kick-Off series has been finalized!

Following the videos introducing iNEXT-Discovery, the virtual Kick-Off meeting, the virtual General Assembly and the Scientific Advisory Board (SAB) meeting, we did not stop! We had virtual meetings also with: The User Panel: we discussed procedures to increase user engagement in the project, to survey user satisfaction, and to find ways to attract new users. A new post-visit questionnaire has been developed, that will be made available to users when their project is finalized, reporting on ...

Apply for free vaccine development services: TRANSVAC2 Open Call

The European vaccine infrastructure, TRANSVAC2, is accepting applications for its Open Call, offering free technical services for all stages of vaccine development. TRANSVAC2, which is coordinated by the European Vaccine Initiative, offers high-quality technical services for the development of prophylactic and therapeutic vaccines for human and animal use. The Open Call covers all stages of the vaccine research and development pipeline, including Instruct-ERIC’s extensive range of structu...

First iNEXT-Discovery publication is about fragment screening!

The first publication to come from iNEXT-Discovery is highlighting the continuation between iNEXT and iNEXT-Discovery. It has been published in the "Journal of Biomolecular NMR" and is about "NMR quality control of fragment libraries for screening". The paper describes how the DSI-poised library of fragments, a collection of 782 fragments assembled aiming to facilitate downstream synthesis of ligands with high affinity by fragment ligation, that was created in Diamond and supported by iNEXT, w...

iNEXT-Discovery Scientific Advisory Board meeting

On Thursday June 11th, the iNEXT-Discovery coordination met with the Scientific Advisory Board during a virtual meeting. The major aims of iNEXT-Discovery were shortly reiterated, as well as the role of the SAB in advising us on the course of the project. Several topics that may require attention for optimal project implementation were discussed, as well as how to prepare the consortium for the longer-term.   ...

The virtual kick-off meeting

The kick-off meeting and the General Assembly took place on Thursday 28 May. Short presentations based on the iNEXT-Discovery introduction video (also available from here) were followed by Q&A sessions.  We had 62 on-line participants, and we tried our best to interact. As life is slowly returning to normal, most of our facilities are now open for remote access, and user projects are taking place....

UK consortium launches COVID-19 Protein Portal to provide essential reagents for national SARS-CoV-2 research

The COVID-19 Protein Portal allows UK scientists to access protein reagents for critical research relating to SARS-CoV-2. Protein reagents are provided free of charge by a consortium of leading UK protein production laboratories, in an Open Science initiative led by Wellcome and UKRI. In response to the urgent need for COVID-19 therapeutics, vaccines and diagnostics, many UK scientists are working to understand the fundamental biology of SARS-CoV-2. Reliable protein reagents are crucial to such...

Covid19-NMR: NMR Structural Biology of SARS-CoV-2

The aim of the international project Covid19-NMR is to determine the 3D structures, in particular of all RNAs, and of all proteins of SARS-CoV-2, or exploit existing structures for subsequent search of drugs guided by these structures. The project is coordinated by Prof. Harald Schwalbe who is a member of the iNEXT-Discovery Executive Board, and will be making use of facilities that particate in the iNEXT-Discovery project. The consortium aims to perform studies to enable the fast screening of ...

Instruct Centre ES launches an online tool to study coronavirus protein information in 3D

Undeterred by the extraordinary circumstances created by the coronavirus pandemic, Instruct ES and INB/ELIXIR-ES scientists have been working hard to deliver tools and resources to support essential COVID-19 research. On 4 May 2020, a team at the Instruct Image Processing Centre (hosted at the Centro Nacional de Biotecnología, CNB-CSIC in Spain) together with INB/ELIXIR-ES launched 3DBionotes-Covid19, a specialised, web-based application for the visualisation and annotation of prote...

In memory of trailblazing Computational Biologist, Prof James Taylor

James Taylor, Ralph S. O'Connor Professor of Biology and Professor of Computer Science at Johns Hopkins University, passed away on 2 April 2020 at the age of 40. James Taylor was a pioneer in computational biology and an advocate for open and reproducible science. James was pivotal in the development of the popular Galaxy platform, which makes computational biology accessible to all scientists, regardless of their computer programming experience. Although Galaxy was initially developed to help ...

Applications for access are now welcome!

While being in turbulent times, we have decided after an inevitable delay due to the current situation, to officially start accepting applications for access to iNEXT-Discovery facilities! We are thus happy to announce to the wider research community this website and welcoming applications. We are posting to the email lists, and social media, so please help us to spread the word! Please do note, that while regardless of current corona-measures external researchers are m...

State-of-the-art cryo-EM installed at Instruct Centre ES

A new, state-of-the-art cryo-electron microscope (cryo-EM) has been installed at Instruct Centre ES following a joint, eight-million-euro investment of the Spanish National Center for Biotechnology (CNB-CSIC) and EU structural funds. The JEOL JEM-Z300FSC (CRYO ARM™ 300) microscope, housed at the CNB-CSIC in Madrid, is the first of its kind to be installed in Spain. The new microscope, together with new correlative microscopy facilities, will be made available to Spanish users and also to E...

Launch of Communication Toolkit for Research Infrastructures

Increasing the visibility of research infrastructures? There’s a toolkit for that. The “Communication Toolkit for European Research Infrastructures” provides an easy and useful set of tools, guidelines and resources to improve the communication strategy and activities of research infrastructures. Its common use is expected to increase the individual and collective visibility of research infrastructures, by aligning key-messages and improving how different stakeholders percei...

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